DuoBioXTM Explore is mammalian and microbial cell culture bioreactor system with leading design, excellent performance, complete functions and easy operation. Users only need one computer to control 1 to 8 glass tanks to run independently or in parallel. In this way, it can greatly speed up the process development progress. The DuoBioXTM Explore system is best choice for the process development study of cell culture in the biopharmaceutical industry.
Concept of design
The DuoBioXTM Explore system fully meets the requirements of bioreactor technology for biopharmaceuticals applications. The process software uses a concise design language which is easy-to-operate. The complete set of electrical components of the controller are from industry leading suppliers and highly integrated with small footprint, saving your precious benchtop space.
Material of construction
The stainless steel parts of the tank in contact with the liquid are made of SUS316L stainless steel, and the inert surface is easy to clean due to electrolytic polishing. The glass body of the tank is made of high quality tempered borosilicate glass, and the sealing material is made of EPDM or silica gel that meets the requirements of FDA. The non-liquid contact part is made of high quality SUS304 stainless steel.
Hardware
Integrate a full set of hardware from industry leading suppliers, ensures stable and reliable system performance:
Germen SIEMENS S-1200 series PLC
Swiss METTLER TOLEDO pH gel sensor
Swiss HAMILTON DO optical sensor
UK Watson-Marlow variable speed peristaltic pump
Japan Panasonic servo stirring motor
Japanese SMC solenoid valve
US Dwyer rotameter
US ALICAT mass flow meter
Advantages
Multiple tank specification options, including 500 mL, 3 L, 7 L and 15 L.
Satellite design provides great flexibility for system expansion, quickly realize multi-connection or parallel control of 1 to 8 tanks, DuoBioXTM Explore system can easily realize parameter setting, process program calling, data backup, and can compare and analyze the trend of different batches under the same interface.
Powerful software functions can realize full control based on feedback, time, conditions and script recipes, which can meet the strict process requirements.
The operating system developed based on the WinCC industrial-grade architecture meets the requirements of GMP and 21 CFR Part 11, and can be used in pharmaceutical and medical industries.
Complete network communication interface, docking with SCADA to realize data collection and remote monitoring.
In addition to basic DO, pH, temperature, liquid level, stirring control unit, the system can provide up to three gas supply channels, including overlay gas supply, macro-sparge bottom gas supply and micro-sparge bottom gas supply, allowing users to design flexible air supply strategy, and easily support high-density perfusion cell culture process; the optimized exhaust gas cooling device can effectively prevent clogging, and is compatible with fermentation/high-density cell culture.
The controller is designed with 2 additional input ports, which can be connected to sensors, such as sensors of cell density, CO2 and weighing, and additional signals can be integrated in control loop.
Model | Explore 500 mL | Explore 3 L | Explore 7 L | Explore 15 L |
Function | Mammalian cell culture (compatible with microorganisms), control up to 8 tanks | |||
Tank | ||||
Working volume | 400 mL | 2 L | 5 L | 10 L |
Max working volume | 500 mL | 3.1 L | 6.8 L | 15 L |
Min working volume | 100 mL | 0.6 L | 1.5 L | 3.2 L |
Aspect ratio | 2:1 | 1.9:1 | 2.2:1 | |
Np value | 1.5 | |||
Blade | 3 pitched blades 45° | |||
Blade diameter | 35 mm | 45 mm | 60 mm | 75 mm |
Gas supply tube diameter | 4 mm | 6 mm | 8 mm | 8 mm |
Macro-sparge diameter | 0.5 mm | 1 mm | ||
Macro-sparge number | 3 | 5 | 7 | 9 |
Micro-sparge pore size | none | 5 μm for optional | ||
Controller | ||||
pH sensor | Inpro3100i/SG/ 225 | Inpro3100i/SG/ 325 | Inpro3100i/SG/ 425 | |
DO sensor | 243666-142/225（optical）H2 | 243666-142/325 （optical）H2 | 243666-142/425 （optical）H2 | |
CO2 sensor | Optional | |||
Overlay | Rotor flow meter （MFC for optional） | |||
MFC-Air | 0~0.1 L | 0~0.5 L | 0~1 L | 0~3 L |
MFC-O2 | 0~0.1 L | 0~0.5 L | 0~1 L | 0~3 L |
MFC-CO2 | 0~0.1 L | 0~0.1 L | 0~0.5 L | 0~1 L |
MFC-N2 | Optional | |||
MFC-O2 micro sparge | 0~0.1 for optional | 0~0.5 for optional | 0~1 for optional | |
Built-in peristaltic pump | 4xWaston Malow 114D variable speed pump | |||
Temperature control | Electric heating base 100w Cold water solenoid valve | |||
Exhaust gas cooling | none | Semiconductor or water cooling | ||
Weighting | Optional | |||
Control software (need to be installed on user's computer) | ||||
21 CFR Part 11 | Yes | |||
Data record | Yes | |||
User authorization management | 4 levels | |||
Utilities requirements | ||||
Gas source | Air、O2、CO2 | |||
Gas source pressure | 0.2-0.3 MPa | |||
Control cabinet power supply | 220 v 50 Hz | |||
Power socket | 10A three-hole | |||
Cabinet dimension | Length*width*height 554*188*404 mm | |||
Single tank external dimensions | Height*diameter 357*100 mm | Height*diameter 430*210 mm | Height*diameter 510*250 mm | Height*diameter 690*280 mm |
Cabinet net weight | 45 kg | |||
Tank net weight | 2 kg | 8 kg | 11 kg | 15 kg |
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