MixQ mixed-mode resin

MixQ virus purification resin is mixed mode resin developed by Bogen (A Duoning Company) for isolation and purification of virus-based products. This product features a core-shell structure. The shell is hydrophilic polymer with defined pore size, due to large size, the virus particles flow through under exclusion effect, while the small impurities pass through the shell and enter the core. The core is polymethacrylate with rigid structure, together with n-octylamine as ligand, which absorbs impurities through ion exchange/hydrophobic interaction, thus separating viruses and impurities.

We provide two types of MixQ virus purification resins: MixQ700 (>MW 700,000) and MixQ400 (>MW 400,000), based on the molecular weight of size exclusion。

Product features：

Mode of virus flow-through, impurity adsorb
Impurity proteins can also be adsorbed at high salt concentrations without buffer exchange
The composition of the virus flow-through solution is same as feed solution, maintaining virus activity

MixQ 复合模式填料

Product Features

	Specifications
Products name	MixQ700S virus purification resin	MixQ700L virus purification resin	MixQ400S virus purification resin	MixQ400L virus purification resin
Average particle size	70 μm	120 μm	70 μm	120 μm
Size exclusion MW	≥700 kD		≥ 400 kD
Max pressure	1 MPa		1 MPa
Matrix	Polyacrylate hard gel		Polyacrylate hard gel
Function group	N-octylamine		N-octylamine
Dynamic binding capacity	≥ 10 mg/ml		≥ 10 mg/ml
pH stability	Resistant to 0.5 M NaOH + 30% IPA clean		Resistant to 0.5 M NaOH + 30% IPA clean
Storage	4-30 ℃（20% ethanol）or 5-10 mM NaOH		4-30 ℃（20% ethanol）or 5-10 mM NaOH